chemokine & GPCR phenotype- and disease-associated variants

Variant information for all human chemokines and receptors was gathered for genome-wide statistical associations between variants and disease- or phenotypic-associated traits. Associations are based on data from ~500,000 individuals from the GeneATLAS database (made available via UK Biobank) (Canela-Xandri et al., 2018. Nature Genetics). Only missense variants were considered. All listed disease-/phenotype-associated variants are below thresholds for significance used in Canela-Xandri, et al. 2018.

The table includes the following columns:

• “protein” - chemokine or GPCR
• “CCN or CRN” - common chemokine or chemokine receptor numbering
• “trait ID” - trait identifier
• “trait description” - trait description
• “consequence” - variant substitution and residue number associated with substitution (unprocessed, N-terminal numbering)
• “p-value” - p-value associated with association