chemokine & GPCR population-level variants

Variant information for all human chemokines and receptors was gathered from >140,000 healthy individuals from the Genome Aggregation Database (GnomAD) (Karczewski et al., 2019, Nature; https://gnomad.broadinstitute.org). Only missense variants were considered.

The table includes the following columns:

• “protein” - chemokine or GPCR
• “CCN or CRN” - common chemokine or chemokine receptor numbering
• “consequence” - variant substitution and residue number associated with substitution (unprocessed, N-terminal numbering); variants are listed using HGVS nomenclature https://varnomen.hgvs.org/recommendations/general/
• “allele count” - number of instances in which given allele (i.e. variant) was identified in population
• “allele count” - total alleles counted at the given position
• “allele frequency” - fraction of instances in which allele is observed relative to the total alleles counted at the given position